RNA Brain Maps

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Air date:	Monday, December 17, 2007, 12:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 126 * This only includes stats from October 2011 and forward.
Category:	Neuroscience
Runtime:	01:11:15
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Dr. Darnell will speak about how brain-specific splicing factors interacting with splicing silencer and enhancer elements lead to RNA isoforms in the brain that are different from the corresponding isoforms in other organs. One of these splicing factors, NOVA, has a predilection for regulating the splicing of RNAs that encode proteins acting at the neuronal synapse. Indeed, in the absence of NOVA in knock-out mice, synaptic NOVA targets are changed in sequence though not in level, with the consequence that LTP of slow inhibitory postsynaptic currents is completely and specifically absent. So, don’t forget splicing when you think of gene expression! And by the way, because NOVA was discovered as a target of an auto-immune reaction in patients with a particular form of a paraneoplastic neurological syndrome, Dr. Darnell’s talk should also be interesting to immunologists and clinicians. NIH Neuroscience Seminar Series

NLM Title:	RNA brain maps / Robert Darnell.
Author:	Darnell, Robert. National Institutes of Health (U.S.)
Publisher:
Abstract:	(CIT): Dr. Darnell will speak about how brain-specific splicing factors interacting with splicing silencer and enhancer elements lead to RNA isoforms in the brain that are different from the corresponding isoforms in other organs. One of these splicing factors, NOVA, has a predilection for regulating the splicing of RNAs that encode proteins acting at the neuronal synapse. Indeed, in the absence of NOVA in knock-out mice, synaptic NOVA targets are changed in sequence though not in level, with the consequence that LTP of slow inhibitory postsynaptic currents is completely and specifically absent. So, don't forget splicing when you think of gene expression! And by the way, because NOVA was discovered as a target of an auto-immune reaction in patients with a particular form of a paraneoplastic neurological syndrome, Dr. Darnell's talk should also be interesting to immunologists and clinicians. NIH Neuroscience Seminar Series.
Subjects:	Brain--physiology Protein Interaction Mapping Protein Isoforms RNA Splicing Synapses--physiology
Publication Types:	Lecture Webcast
NLM Classification:	WL 102.8
NLM ID:	101463227
CIT Live ID:	6173
Permanent link:	https://videocast.nih.gov/watch=6173

NIH VideoCasting