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Exploring Genetic Dependencies in Ras Mutant Cancer CellsHHS Only

Air date: Friday, March 4, 2016, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Description: NCI’s Center for Cancer Research (CCR) Grand Rounds

Dr. Ji Luo received his B.A. in Natural Sciences from the University of Cambridge, UK in 1998. He completed his Ph.D. training as an HHMI Predoctoral Fellow in the laboratory of Dr. Lewis Cantley at Harvard University, Boston. His Ph.D. research focused on the role of PI 3-kinase in development, diabetes and cancer. Ji Luo undertook his postdoctoral training as an AACR Fellow in the laboratory of Dr. Stephen Elledge at Harvard Medical School, Boston. His postdoctoral research focused on the development of bar-coded shRNA library technologies for genome-wide RNAi synthetic lethal analysis in cancer cells.

His lab focuses on understanding the biology of cancer with mutations in the Ras oncogene. In particular, we are using functional genomics to dissect genetic dependencies and delineate mechanisms of non-oncogene addiction in Ras mutant cells. We are currently investigating the role of SUMO ligases, RNA splicing factors, and certain transcriptional factors support the malignancy of cancer cells with Ras mutation. In addition, we are developing new RNAi and CRISPR tools to identify druggable target combinations in KRAS mutant cells. Lastly, we have developed pharmacological synthetic lethal screens to discovery new therapeutic strategies that can be rapidly translated into clinical trials.
Author: Ji Luo Ph.D., Head, Cancer Systems Biology Section, Laboratory of Cancer Biology and Genetics Center for Cancer Research, NCI, NIH
Runtime: 1 hour