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Human antibody responses to SARS-CoViD-2

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Air date: Wednesday, October 7, 2020, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 1,346 (829 Live, 517 On-demand)
Category: WALS - Wednesday Afternoon Lectures
Runtime: 01:04:09
Description: NIH Director's Wednesday Afternoon Lecture Series

This will be the 5th Annual William E. Paul Lecture to honor the legacy of our colleague Dr. Paul, a shining icon and an international giant of contemporary immunology who had an enormous impact on the research career of his trainees, many of whom became leaders in the immunology field. Dr. Paul died in 2015.

Dr. Nussenzweig is the Zanvil A. Cohn and Ralph M. Steinman Professor at The Rockefeller University, New York, and a Howard Hughes Medical Institute Investigator. Nussenzweig's laboratory studies the molecular aspects of the immune system's innate and adaptive responses using a combination of biochemistry, molecular biology, and genetics. His work is leading to new antibody-based therapies for infections by HIV and the novel SARS-CoV-2 coronavirus, among other viruses.

Dr. Nussenzweig will speak about the development of antibody responses focusing on neutralizing antibody responses to SARS-CoViD-2. Over a decade ago, the Nussenzweig laboratory developed methods for rapid antibody cloning from humans in order to understand humoral immune responses to pathogens beginning with HIV-1. These methods have been widely adapted by others facilitating antibody cloning for multiple human pathogens and their clinical development. At the start of the COVID-19 pandemic a group of 148 individuals that had recovered from SARS-CoV-2 infection were recruited to Rockefeller University to give blood for analysis. The lecture will summarize features of their humoral immune response in these individuals and their neutralizing properties in vitro and in animal models.

For more information go to https://oir.nih.gov/wals/about-wals
NLM Title: Human antibody responses to SARS-CoViD-2 / Michel Nussenzweig.
Author: Nussenzweig, Michel.
National Institutes of Health (U.S.),
Publisher:
Abstract: (CIT): Dr. Nussenzweig will speak about the development of antibody responses focusing on neutralizing antibody responses to SARS-CoViD-2. Over a decade ago, the Nussenzweig laboratory developed methods for rapid antibody cloning from humans in order to understand humoral immune responses to pathogens beginning with HIV-1. These methods have been widely adapted by others facilitating antibody cloning for multiple human pathogens and their clinical development. At the start of the COVID-19 pandemic a group of 148 individuals that had recovered from SARS-CoV-2 infection were recruited to Rockefeller University to give blood for analysis. The lecture will summarize features of their humoral immune response in these individuals and their neutralizing properties in vitro and in animal models.
Subjects: Antibodies, Neutralizing--immunology
Antibody Formation
Coronavirus Infections--immunology
SARS Virus--immunology
Severe Acute Respiratory Syndrome--immunology
Publication Types: Lecture
Webcast
 
NLM Classification: QW 168.5.C8
NLM ID: 101773030
CIT Live ID: 38684
Permanent link: https://videocast.nih.gov/watch=38684

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