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Marathons for T Cells: How They Keep on Killing

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Air date: Wednesday, June 15, 2022, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 633 (339 Live, 294 On-demand)
Category: WALS - Wednesday Afternoon Lectures
Runtime: 00:54:15
Description: This WALS talk is jointly sponsored with the IIG. Dr. Griffiths is a Wellcome Trust Principal Research Fellow and a professor of immunology and cell biology at Cambridge Institute for Medical Research. For this lecture, Dr. Griffiths will focus on the cell biology that underlies the remarkable ability of cytotoxic T lymphocytes to act as serial killers, with individual cells providing sustained killing in response to cancer or virally infected targets. She will describe a screen that picked up genes that are required for sustained killing and revealed an unexpected role for mitochondria as homestatic regulators of CTL killing. She then will describe work by a former NIH-OxCam student that reveals an (again unexpected) role for transcription during killing.

For more information go to https://oir.nih.gov/wals
NLM Title: Marathons for T cells : how they keep on killing / Gillian Griffiths.
Author: Griffiths, G M.
National Institutes of Health (U.S.),
Publisher:
Abstract: (CIT): This WALS talk is jointly sponsored with the IIG. Dr. Griffiths is a Wellcome Trust Principal Research Fellow and a professor of immunology and cell biology at Cambridge Institute for Medical Research. For this lecture, Dr. Griffiths will focus on the cell biology that underlies the remarkable ability of cytotoxic T lymphocytes to act as serial killers, with individual cells providing sustained killing in response to cancer or virally infected targets. She will describe a screen that picked up genes that are required for sustained killing and revealed an unexpected role for mitochondria as homestatic regulators of CTL killing. She then will describe work by a former NIH-OxCam student that reveals an (again unexpected) role for transcription during killing.
Subjects: T-Lymphocytes, Cytotoxic--immunology
T-Lymphocytes, Cytotoxic--physiology
Publication Types: Lecture
Webcast
 
NLM Classification: WH 200
NLM ID: 9918434185206676
CIT Live ID: 44268
Permanent link: https://videocast.nih.gov/watch=44268

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