NIH VideoCast - BME Lecture: Matrix Viscoelasticity and Cancer

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BME Lecture: Matrix Viscoelasticity and Cancer

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Air date:	Tuesday, February 14, 2023, 1:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 189 (126 Live, 63 On-demand)
Category:	Special
Runtime:	01:00:39
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Changes in matrix stiffness is increasingly appreciated as a key variable in cancer research, but most current work ignores that tissues are viscoelastic, with time-dependent mechanical behavior. Using biomaterials that allow independent control over key variables, we find that the rate of matrix stress relaxation has dramatic effects on stem cell fate, and impacts multiple cell types in the tumor microenvironment, including cancer cells, monocytes, and T cells. Inspired by the importance of viscoelasticity to extracellular matrix, new medical adhesives are being synthesized from energy dissipative hydrogel networks. For more information go to https://wyss.harvard.edu/team/core-faculty/david-mooney/

NLM Title:	Matrix viscoelasticity and cancer / David Mooney.
Author:	Mooney, David J. National Institutes of Health (U.S.). Biomedical Engineering Scientific Interest Group,
Publisher:
Abstract:	(CIT): Changes in matrix stiffness is increasingly appreciated as a key variable in cancer research, but most current work ignores that tissues are viscoelastic, with time-dependent mechanical behavior. Using biomaterials that allow independent control over key variables, we find that the rate of matrix stress relaxation has dramatic effects on stem cell fate, and impacts multiple cell types in the tumor microenvironment, including cancer cells, monocytes, and T cells. Inspired by the importance of viscoelasticity to extracellular matrix, new medical adhesives are being synthesized from energy dissipative hydro gel networks.
Subjects:	Extracellular Matrix--physiology Viscoelastic Substances
Publication Types:	Lecture Webcast

NLM Classification:	QU 350
NLM ID:	9918573160106676
CIT Live ID:	48988
Permanent link:	https://videocast.nih.gov/watch=48988

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