NIH VideoCast - The Generation of Cortical Interneuron Diversity: Both Nurture and Nature

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The Generation of Cortical Interneuron Diversity: Both Nurture and Nature

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Air date:	Monday, February 2, 2015, 12:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 339 (56 Live, 283 On-demand)
Category:	Neuroscience
Runtime:	01:12:43
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Neuroscience Seminar Series The Fishell laboratory is focused on how the diversity of local circuit GABAergic inhibitory interneurons is created. Understanding how this is accomplished during development remains one of the most daunting problems in biology. In particular, they wish to understand not only how the vast variety of inhibitory interneuron subtypes are generated but how they subsequently integrate into the bewildering array of neural circuits that are embedded in different brain structures. Their working hypothesis is that this is achieved through a two-step process. The first involves genetic programs that in accordance with their birthdate create a finite number of cardinal interneuron subtypes (Research Topic 1 - The Embryonic Specification of Interneurons). Following the tiling of these newly born cardinal subtypes across different brain structures, local cues act to create the definitive subtypes characteristic of the distinct cortical and subcortical areas (Research Topic 2 - Interneuron Integration and Synapse Formation). Importantly, as they have explored the molecular control of these events, it has become clear that perturbation of this process can result in a variety of brain dysfunctions including autism spectrum disorder (ASD), intellectual disability (ID) and schizophrenia. A new and growing interest in the laboratory is therefore aimed at seeing if better understanding of these developmental events can lead to the development of new treatments for these disorders (Research Topic 3 - Interneuron Function and Dysfunction).

NLM Title:	The generation of cortical interneuron diversity : both nurture and nature / Gordon Fishell.
Author:	Fishell, Gord. National Institutes of Health (U.S.),
Publisher:
Abstract:	(CIT): The Fishell laboratory is focused on how the diversity of local circuit GABAergic inhibitory interneurons is created. Understanding how this is accomplished during development remains one of the most daunting problems in biology. In particular, they wish to understand not only how the vast variety of inhibitory interneuron subtypes are generated but how they subsequently integrate into the bewildering array of neural circuits that are embedded in different brain structures. Their working hypothesis is that this is achieved through a two-step process. The first involves genetic programs that in accordance with their birthdate create a finite number of cardinal interneuron subtypes (Research Topic 1 - The Embryonic Specification of Interneurons). Following the tiling of these newly born cardinal subtypes across different brain structures, local cues act to create the definitive subtypes characteristic of the distinct cortical and subcortical areas (Research Topic 2 - Interneuron Integration and Synapse Formation). Importantly, as they have explored the molecular control of these events, it has become clear that perturbation of this process can result in a variety of brain dysfunctions including autism spectrum disorder (ASD), intellectual disability (ID) and schizophrenia. A new and growing interest in the laboratory is therefore aimed at seeing if better understanding of these developmental events can lead to the development of new treatments for these disorders (Research Topic 3 - Interneuron Function and Dysfunction).
Subjects:	Cerebral Cortex Genetic Variation Interneurons--classification Interneurons--physiology
Publication Types:	Lecture Webcast

NLM Classification:	WL 102.5
NLM ID:	101653995
CIT Live ID:	14984
Permanent link:	https://videocast.nih.gov/watch=14984

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