NIH VideoCast - Group 1 innate lymphoid cells in metabolic disease

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Group 1 innate lymphoid cells in metabolic disease

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Air date:	Wednesday, January 25, 2017, 4:15:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 341 (51 Live, 290 On-demand)
Category:	Immunology
Runtime:	00:56:51
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Immunology Interest Group Seminar Series Innate lymphoid cells (ILCs) are the most recently identified arm of the innate immune system that function to protect epithelial barriers against pathogens and maintain tissue homeostasis. Although ILCs can also promote pathology at mucosal sites such as the gut or lung, it remains unknown whether aberrant activation of tissue-resident ILCs can contribute to disease in non-barrier tissues. Here, we identify a subset of long-term adipose-resident ILC1 that are dependent on the transcription factors Nfil3 and T-bet, but phenotypically and functionally distinct from circulating mature natural killer cells. Diet-induced obesity drove early proinflammatory cytokine production in adipose tissue depots, leading to selective proliferation and accumulation of adipose-resident ILC1s. ILC1-derived IFN-γ was both necessary and sufficient to drive proinflammatory macrophage polarization to promote obesity-associated insulin resistance. Therefore, these findings suggest that adipose-resident ILC1s contribute to metabolic disease in response to dysregulated local inflammation. Dr. Joseph Sun obtained his Ph.D. degree from the Department of Immunology, University of Washington, where he worked in Dr. Michael Bevan’s laboratory on the role of CD4 T cells in the generation and maintenance of CD8 T cell memory. He then received his postdoctoral training in the Department of Microbiology and Immunology, UCSF, with Dr. Lewis L. Lanier, where he discovered NK cell “memory”. In 2010, Joe was recruited as an Assistant Member, to the Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY. Joe continued to pursue his interests in both immunological memory and NK cell biology. This body of work includes all facets of NK cell biology, from development to function to longevity. A seminal work from his lab demonstrated the critical function of RAG recombinase in dictating NK cell development, effector function, and survival. Joe has been highly productive, and was promoted to Associate Member last year.

NLM Title:	Group 1 innate lymphoid cells in metabolic disease / Joseph C. Sun ; Immunology Interest Group.
Author:	Sun, Joseph C. National Institutes of Health (U.S.). Immunology Interest Group,
Publisher:
Abstract:	(CIT): Immunology Interest Group Seminar Series. Innate lymphoid cells (ILCs) are the most recently identified arm of the innate immune system that function to protect epithelial barriers against pathogens and maintain tissue homeostasis. Although ILCs can also promote pathology at mucosal sites such as the gut or lung, it remains unknown whether aberrant activation of tissue-resident ILCs can contribute to disease in non-barrier tissues. Here, we identify a subset of long-term adipose-resident ILC1 that are dependent on the transcription factors Nfil3 and T-bet, but phenotypically and functionally distinct from circulating mature natural killer cells. Diet-induced obesity drove early proinflammatory cytokine production in adipose tissue depots, leading to selective proliferation and accumulation of adipose-resident ILC1s. ILC1-derived IFN-y was both necessary and sufficient to drive proinflammatory macrophage polarization to promote obesity-associated insulin resistance. Therefore, these findings suggest that adipose-resident ILC1s contribute to metabolic disease in response to dysregulated local inflammation. Dr. Joseph Sun obtained his Ph.D. degree from the Department of Immunology, University of Washington, where he worked in Dr. Michael Bevan's laboratory on the role of CD4 T cells in the generation and maintenance of CD8 T cell memory. He then received his postdoctoral training in the Department of Microbiology and Immunology, UCSF, with Dr. Lewis L. Lanier, where he discovered NK cell memory. In 2010, Joe was recruited as an Assistant Member, to the Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY. Joe continued to pursue his interests in both immunological memory and NK cell biology. This body of work includes all facets of NK cell biology, from development to function to longevity. A seminal work from his lab demonstrated the critical function of RAG recombinase in dictating NK cell development, effector function, and survival. Joe has been highly productive, and was promoted to Associate Member last year.
Subjects:	Adipose Tissue--immunology Immunity, Innate Lymphocytes Metabolic Syndrome--immunology Obesity--immunology
Publication Types:	Lecture Webcast

NLM Classification:	WK 820
NLM ID:	101700300
CIT Live ID:	18546
Permanent link:	https://videocast.nih.gov/watch=18546

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