1c:{"metadata":[["$","title","0",{"children":"NIH VideoCast - Phosphoinositide 3-Kinase Pathway and Human Disease"}],["$","meta","1",{"name":"description","content":"Phosphoinositide 3-kinase (PI3K) is activated by a host of hormones and growth factors and produces membrane bound lipid second messengers that are implicated in complex cellular events such as cell survival, cell growth, cell cycle entry and chemotaxis, based on ex-vivo experiments. We have used a variety of approaches to map protein kinase pathways upstream and downstream of PI3K. In addition, we have manipulated genes in the mouse to assess the role of PI3K and downstream responses in normal development, in insulin signaling and in cancers. These studies have revealed a tightly regulated and highly conserved signaling network, perturbations of which can result in a wide variety of diseases, including cancers, tuberous sclerosis and type 2 diabetes.\n
\n
\nFor more information, visit
\nhttp://www.fas.harvard.edu/%7Ebiophys/Lewis_Cantley.htm\n
\n
\nWALS
"}],["$","meta","2",{"name":"publisher","content":"National Institutes of Health"}],["$","meta","3",{"property":"og:title","content":"NIH VideoCast - Phosphoinositide 3-Kinase Pathway and Human Disease"}],["$","meta","4",{"property":"og:description","content":"Phosphoinositide 3-kinase (PI3K) is activated by a host of hormones and growth factors and produces membrane bound lipid second messengers that are implicated in complex cellular events such as cell survival, cell growth, cell cycle entry and chemotaxis, based on ex-vivo experiments. We have used a variety of approaches to map protein kinase pathways upstream and downstream of PI3K. In addition, we have manipulated genes in the mouse to assess the role of PI3K and downstream responses in normal development, in insulin signaling and in cancers. These studies have revealed a tightly regulated and highly conserved signaling network, perturbations of which can result in a wide variety of diseases, including cancers, tuberous sclerosis and type 2 diabetes.\n
\n
\nFor more information, visit
\nhttp://www.fas.harvard.edu/%7Ebiophys/Lewis_Cantley.htm\n
\n
\nWALS
"}],["$","meta","5",{"property":"og:url","content":"https://uat.d1rkikwu4q8tg.amplifyapp.com/watch/98709d8b-d5db-11f0-9cf9-12c45c580ad9"}],["$","meta","6",{"property":"og:site_name","content":"NIH VideoCast"}],["$","meta","7",{"property":"og:image","content":"https://nihcit.rev.vbrick.com/api/v2/media/videos/thumbnails/d48e746c-14a1-42bf-9da5-00c95f83611e.jpg"}],["$","meta","8",{"property":"og:type","content":"website"}],["$","meta","9",{"name":"twitter:card","content":"summary_large_image"}],["$","meta","10",{"name":"twitter:title","content":"NIH VideoCast - Phosphoinositide 3-Kinase Pathway and Human Disease"}],["$","meta","11",{"name":"twitter:description","content":"Phosphoinositide 3-kinase (PI3K) is activated by a host of hormones and growth factors and produces membrane bound lipid second messengers that are implicated in complex cellular events such as cell survival, cell growth, cell cycle entry and chemotaxis, based on ex-vivo experiments. We have used a variety of approaches to map protein kinase pathways upstream and downstream of PI3K. In addition, we have manipulated genes in the mouse to assess the role of PI3K and downstream responses in normal development, in insulin signaling and in cancers. These studies have revealed a tightly regulated and highly conserved signaling network, perturbations of which can result in a wide variety of diseases, including cancers, tuberous sclerosis and type 2 diabetes.\n
\n
\nFor more information, visit
\nhttp://www.fas.harvard.edu/%7Ebiophys/Lewis_Cantley.htm\n
\n
\nWALS
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