NIH VideoCast - The Broad Impact of NLRs on Immunity and Beyond

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The Broad Impact of NLRs on Immunity and Beyond

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Air date:	Wednesday, February 5, 2014, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 401 (133 Live, 268 On-demand)
Category:	WALS - Wednesday Afternoon Lectures
Runtime:	00:59:54
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Wednesday Afternoon Lecture Series Dr. Jenny Ting is the discoverer of the NLR gene family and co-director of the Inflammatory Diseases Institute at the UNC School of Medicine. Her research is at the intersection of neurobiology and immunology and its relation to cancer and autoimmune diseases such as multiple sclerosis. The innate immune system is governed by a variety of receptors or sensors that detect microbial pathogens and activate specific signaling pathways. More important, these receptors/sensors also have a great impact on the basic biologic processes that affect cancer, metabolic disorders, inflammation, neurologic disorders, and other diseases. The Ting group first reported on the large human NLR gene family, which comprises regulators of innate immunity and exhibits important regulatory roles in immunity and beyond. These genes provide instructions for making proteins called nucleotide-binding domain and leucine-rich repeat containing (NLR) proteins, which are involved in starting and regulating the immune system's response to injury, toxins, or invasion by bacteria, viruses, and fungi. The NLR family also affects a number of processes that are involved in sterile inflammation and adaptive immunity. Many of the NLR proteins control immunity by regulating cytokine production (such as the inflammasome products IL-1beta/IL-18 and interferons), while some directly control gene expression (such as the class I and II major histocompatibility genes). Members also regulate diverse cell-death responses such as apoptosis, necrosis, and autophagy, and diverse signaling pathways including NFkB and MAPKs. Dr. Ting will present evidence for the broad biologic and clinical impact of the NLR family and describe findings regarding novel NLRs. For more information go to http://wals.od.nih.gov/

NLM Title:	The broad impact of NLRs on immunity and beyond / Jenny Ting.
Author:	Ting, Jenny. National Institutes of Health (U.S.),
Publisher:
Abstract:	(CIT): Wednesday Afternoon Lecture Series Dr. Jenny Ting is the discoverer of the NLR gene family and co-director of the Inflammatory Diseases Institute at the UNC School of Medicine. Her research is at the intersection of neurobiology and immunology and its relation to cancer and autoimmune diseases such as multiple sclerosis. The innate immune system is governed by a variety of receptors or sensors that detect microbial pathogens and activate specific signaling pathways. More important, these receptors/sensors also have a great impact on the basic biologic processes that affect cancer, metabolic disorders, inflammation, neurologic disorders, and other diseases. The Ting group first reported on the large human NLR gene family, which comprises regulators of innate immunity and exhibits important regulatory roles in immunity and beyond. These genes provide instructions for making proteins called nucleotide-binding domain and leucine-rich repeat containing (NLR) proteins, which are involved in starting and regulating the immune system's response to injury, toxins, or invasion by bacteria, viruses, and fungi. The NLR family also affects a number of processes that are involved in sterile inflammation and adaptive immunity. Many of the NLR proteins control immunity by regulating cytokine production (such as the inflammasome products IL-1beta/IL-18 and interferons), while some directly control gene expression (such as the class I and II major histocompatibility genes). Members also regulate diverse cell-death responses such as apoptosis, necrosis, and autophagy, and diverse signaling pathways including NFkB and MAPKs. Dr. Ting will present evidence for the broad biologic and clinical impact of the NLR family and describe findings regarding novel NLRs. For more information go to http://wals.od.nih.gov/.
Subjects:	DNA-Binding Proteins--physiology Receptors, Cell Surface--physiology
Publication Types:	Lecture Webcast

NLM Classification:	QU 58.5
NLM ID:	101628101
CIT Live ID:	13714
Permanent link:	https://videocast.nih.gov/watch=13714

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