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Director's Seminar Series

HIV infection leads to CD4 lymphopenia and immunosuppression, which can be successfully improved with antiretroviral therapy (ART) but approximately 20 percent of HIV patients initiating ART may develop an aberrant immune response known as immune reconstitution inflammatory syndrome (IRIS). IRIS encompasses the paradoxical worsening of the manifestations of underlying opportunistic diseases (paradoxical IRIS) or the abrupt or atypical presentation of previously occult opportunistic disease (unmasking IRIS) in patients who recently started ART. Importantly, IRIS or paradoxical reactions seem to expand beyond HIV representing a dysregulation of immune responses when immune suppression is abruptly reversed.Our group is studying the clinical predictors, biomarkers and pathogenesis of IRIS through a comprehensive translational program with the aim to develop better strategies for prevention and treatment.

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Director's Seminar Series

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Director's Seminar Series

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