NIH VideoCast - Type I interferon induction and exhaustion upon viral infection

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Type I interferon induction and exhaustion upon viral infection

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Air date:	Wednesday, September 23, 2020, 4:15:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 966 (189 Live, 777 On-demand)
Category:	Immunology
Runtime:	01:12:21
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	IIG Seminar Dr. Zuniga’s laboratory discovered that, in response to a viral infection, systemic type I interferons (IFN-I) are initially elevated but are subsequently and rapidly silenced despite continuous pathogen replication. They showed that there is an IFN-I refractory (or exhaustion) phase, during which the infected host fails to elevate IFN-I upon secondary unrelated infections, explaining delayed viral control and enhanced susceptibility to opportunistic infections. Dr. Zuniga will present their recent work on the mechanisms underlying the initial IFN-I elevation and its subsequent, rapid, suppression after viral infection. For more information go to https://www.niaid.nih.gov/research/immunology-interest-group

NLM Title:	Type I interferon induction and exhaustion upon viral infection / Elina Zuniga.
Author:	Zuniga, Elina. National Institutes of Health (U.S.),
Publisher:
Abstract:	(CIT): Dr. Zuniga's laboratory discovered that, in response to a viral infection, systemic type I interferons (IFN-I) are initially elevated but are subsequently and rapidly silenced despite continuous pathogen replication. They showed that there is an IFN-I refractory (or exhaustion) phase, during which the infected host fails to elevate IFN-I upon secondary unrelated infections, explaining delayed viral control and enhanced susceptibility to opportunistic infections. Dr. Zuniga will present their recent work on the mechanisms underlying the initial IFN-I elevation and its subsequent, rapid, suppression after viral infection.
Subjects:	Interferon Type I--immunology Virus Diseases--immunology Virus Diseases--virology
Publication Types:	Lecture Webcast

NLM Classification:	WC 500
NLM ID:	101772209
CIT Live ID:	38716
Permanent link:	https://videocast.nih.gov/watch=38716

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