NIH VideoCast - Hematology from the Ground-Up: Lessons from Bloodless Worms

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Hematology from the Ground-Up: Lessons from Bloodless Worms

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Air date:	Wednesday, November 16, 2022, 2:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 195 (108 Live, 87 On-demand)
Category:	WALS - Wednesday Afternoon Lectures
Runtime:	01:04:16
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	NIH Director’s Wednesday Afternoon Lecture Series Our long-term objectives are to identify the genes and pathways responsible for heme transport and trafficking in eukaryotes that have remained poorly understood. Many have a preconceived notion that the bulk of heme biology is well-understood. How does heme, a cytotoxic hydrophobic ring with an iron atom, moves within and between cells? How does heme traffic across cellular membranes and get into hemoglobin? These open questions are enormous holes in our knowledge. The central thrust of our research is to uncover these pathways using a multi-organismal, multi-pronged approach. Our pioneering work with the invertebrate animal model C. elegans demonstrated that this roundworm is exceptional because it does not synthesize heme but rather utilizes environmental heme to manufacture heme-containing proteins that have human homologs. The presentation will highlight efforts in the Hamza lab to understand the mechanistic aspects of heme trafficking as well as how functional insights into these processes lay the groundwork for elucidating the molecular etiology of human disease and parasitic infections. For more information go to https://oir.nih.gov/wals

NLM Title:	Hematology from the ground-up : lessons from bloodless worms / Iqbal Hamza.
Author:	Hamza, Iqbal. National Institutes of Health (U.S.),
Publisher:
Abstract:	(CIT): NIH Director"s Wednesday Afternoon Lecture Series. Our long-term objectives are to identify the genes and pathways responsible for heme transport and trafficking in eukaryotes that have remained poorly understood. Many have a preconceived notion that the bulk of heme biology is well-understood. How does heme, a cytotoxic hydrophobic ring with an iron atom, moves within and between cells? How does heme traffic across cellular membranes and get into hemoglobin? These open questions are enormous holes in our knowledge. The central thrust of our research is to uncover these pathways using a multi-organismal, multi-pronged approach. Our pioneering work with the invertebrate animal model C. elegans demonstrated that this roundworm is exceptional because it does not synthesize heme but rather utilizes environmental heme to manufacture heme-containing proteins that have human homologs. The presentation will highlight efforts in the Hamza lab to understand the mechanistic aspects of heme trafficking as well as how functional insights into these processes lay the groundwork for elucidating the molecular etiology of human disease and parasitic infections.
Subjects:	Caenorhabditis elegans Heme--metabolism
Publication Types:	Lecture Webcast

NLM Classification:	WH 190
NLM ID:	9918573264606676
CIT Live ID:	46015
Permanent link:	https://videocast.nih.gov/watch=46015

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