NIH VideoCast - Molecular Arms Races Shape the Evolution and Function of Antiviral Proteins

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Molecular Arms Races Shape the Evolution and Function of Antiviral Proteins

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Air date:	Wednesday, June 21, 2023, 2:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 494 (355 Live, 139 On-demand)
Category:	WALS - Wednesday Afternoon Lectures
Runtime:	01:08:22
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	NIH Director’s Wednesday Afternoon Lecture Series The Malik lab studies the causes and consequences of genetic conflicts that take place between different genomes (e.g., host-virus interactions, mitochondrial conflicts with nuclear genomes) or between components of the same genome (e.g., chromosomal competition at centromeric regions). We are interested in understanding these "molecular arms races" and how they drive recurrent genetic innovation, from the perspective of both evolutionary biology and human disease. Malik and his colleagues have used an evolutionary lens to dissect and discover both primate antiviral as well as viral adaptation strategies. This lecture will describe how we use evolution-guided mutagenesis approaches to dissect and enhance the function of antiviral proteins. For more information go to https://oir.nih.gov/wals

NLM Title:	Molecular arms races shape the evolution and function of antiviral proteins / Harmit Malik.
Author:	Malik, Harmit S. National Institutes of Health (U.S.),
Publisher:
Abstract:	(CIT): NIH Director's Wednesday Afternoon Lecture Series The Malik lab studies the causes and consequences of genetic conflicts that take place between different genomes (e.g., host-virus interactions, mitochondrial conflicts with nuclear genomes) or between components of the same genome (e.g., chromosomal competition at centromeric regions). We are interested in understanding these "molecular arms races" and how they drive recurrent genetic innovation, from the perspective of both evolutionary biology and human disease. Malik and his colleagues have used an evolutionary lens to dissect and discover both primate antiviral as well as viral adaptation strategies. This lecture will describe how we use evolution-guided mutagenesis approaches to dissect and enhance the function of antiviral proteins.For more information go to https://oir.nih.gov/wals.
Subjects:	Antiviral Agents--pharmacology Genome, Viral Models, Molecular Mutagenesis--genetics Viral Proteins--genetics
Publication Types:	Lecture Webcast

NLM Classification:	QW 160
NLM ID:	9918663184906676
CIT Live ID:	46097
Permanent link:	https://videocast.nih.gov/watch=46097

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