NIH VideoCast - Specifying the T Cell Fates Required for Immunity

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Specifying the T Cell Fates Required for Immunity

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Air date:	Wednesday, October 10, 2007, 4:15:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 130 * This only includes stats from October 2011 and forward.
Category:	Immunology
Runtime:	01:05:45
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	The Reiner laboratory studies how lymphocytes make decisions during the course of an immune response, in particular, the decision of which type of effector cell a helper T cell becomes upon encounter with antigen. In vivo approaches utilize infectious disease model systems such as challenge with Leishmania major. In vitro studies examine the relationship between the cell cycle and cellular differentiation, as well as the mechanisms whereby chromatin structure and cytosine methylation regulate gene expression. The molecular basis of many of the unique properties of lymphocytes, such as their "memory", can be understood by how genes are silenced and activated. In addition, the study of lymphocyte differentiation has implications for how the genome is regulated during evolution and how cells make decisions during many developmental stages. His recent work has focused on asymmetric division in T cells and on the impact of T-bet and Eomesodermin as they affect lymphocyte function and self-renewal. His “one cell, multiple fates” model is clearly elucidated in his perspective published in Science. 2007 Aug 3;317(5838):622-5. Entitled ”Division of labor with a workforce of one: challenges in specifying effector and memory T cell fate.” http://www.sciencemag.org/cgi/content/full/317/5838/622 The Immunology Interest Group (IIG) organizes activities designed to promote information exchange and interactions among NIH scientists interested in the field of immunology, broadly defined. Interactions are facilitated via weekly meetings on current topics as well as an annual Immunology Retreat. For more information, visit The Immunology Interest Group

NLM Title:	Specifying the T cell fates required for immunity / Steven L. Reiner.
Author:	Reiner, Steve. National Institutes of Health (U.S.). Immunology Interest Group.
Publisher:
Abstract:	(CIT): The Reiner laboratory studies how lymphocytes make decisions during the course of an immune response, in particular, the decision of which type of effector cell a helper T cell becomes upon encounter with antigen. In vivo approaches utilize infectious disease model systems such as challenge with Leishmania major. In vitro studies examine the relationship between the cell cycle and cellular differentiation, as well as the mechanisms whereby chromatin structure and cytosine methylation regulate gene expression. The molecular basis of many of the unique properties of lymphocytes, such as their "memory", can be understood by how genes are silenced and activated. In addition, the study of lymphocyte differentiation has implications for how the genome is regulated during evolution and how cells make decisions during many developmental stages.
Subjects:	Immunity, Cellular--immunology T-Lymphocytes--immunology
Publication Types:	Lecture Webcast
NLM Classification:	QW 568
NLM ID:	101319975
CIT Live ID:	6126
Permanent link:	https://videocast.nih.gov/watch=6126

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