NIH VideoCast - An MHC-independent macromolecular ligand for a human tumor-reactive a/b T-cell receptor

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An MHC-independent macromolecular ligand for a human tumor-reactive a/b T-cell receptor

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Air date:	Wednesday, March 31, 2010, 4:15:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 118 * This only includes stats from October 2011 and forward.
Category:	Immunology
Runtime:	00:48:31
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Dr. Ken-ichi Hanada received his MD from the Tokyo Medical and Dental University and completed a residency in Internal Medicine at that University Hospital. He then completed his PhD and post graduate work in the Department of Biochemistry at the University of Tokyo. He was involved in the identification of the murine hematopoetic stem cell during post-graduate work and as a research member of the Japanese Foundation for Cancer Research. In 1997 he arrived as an Exchange Scientist in the Surgery Branch, NCI. As a Research Fellow and then a Staff Scientist, he has been involved in studying the cellular immune response to human renal cancer. In 2004, he published the first description of vertebrate post-translational protein splicing in Nature, when he identified the spliced epitope from a renal cancer antigen recognized by a T-cell. Now pursuing new T-cell reactivities which can recognize renal cancer, he has elucidated the molecular basis for an unprecedented ligand which can trigger a human alpha-beta T-cell receptor. The Immunology Interest Group

NLM Title:	An MHC-independent macromolecular ligand for a human tumor-reactive [alpha-beta] T-cell receptor / Ken-ichi Hanada.
Author:	Hanada, Ken-ichi. National Institutes of Health (U.S.). Immunology Interest Group.
Publisher:
Abstract:	(CIT): Dr. Ken-ichi Hanada received his MD from the Tokyo Medical and Dental University and completed a residency in Internal Medicine at that University Hospital. He then completed his PhD and post graduate work in the Department of Biochemistry at the University of Tokyo. He was involved in the identification of the murine hematopoetic stem cell during post-graduate work and as a research member of the Japanese Foundation for Cancer Research. In 1997 he arrived as an Exchange Scientist in the Surgery Branch, NCI. As a Research Fellow and then a Staff Scientist, he has been involved in studying the cellular immune response to human renal cancer. In 2004, he published the first description of vertebrate post-translational protein splicing in Nature, when he identified the spliced epitope from a renal cancer antigen recognized by a T-cell. Now pursuing new T-cell reactivities which can recognize renal cancer, he has elucidated the molecular basis for an unprecedented ligand which can trigger a human alpha-beta T-cell receptor. The Immunology Interest Group.
Subjects:	Major Histocompatibility Complex--immunology Multiprotein Complexes--immunology Neoplasms--immunology Receptors, Antigen, T-Cell, alpha-beta--immunology
Publication Types:	Lecture Webcast
NLM Classification:	QW 573
NLM ID:	101531541
CIT Live ID:	8337
Permanent link:	https://videocast.nih.gov/watch=8337

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